Correcting Base-Assignment Errors in Repeat Regions of Shotgun Assembly
نویسندگان
چکیده
منابع مشابه
Correcting errors in shotgun sequences.
Sequencing errors in combination with repeated regions cause major problems in shotgun sequencing, mainly due to the failure of assembly programs to distinguish single base differences between repeat copies from erroneous base calls. In this paper, a new strategy designed to correct errors in shotgun sequence data using defined nucleotide positions, DNPs, is presented. The method distinguishes ...
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Shotgun Sequence Assembly
Shotgun sequencing is the most widely used technique for determining the DNA sequence of organisms. It involves breaking up the DNA into many small pieces that can be read by automated sequencing machines, then piecing together the original genome using specialized software programs called assemblers. Due to the large amounts of data being generated and to the complex structure of most organism...
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ژورنال
عنوان ژورنال: IEEE/ACM Transactions on Computational Biology and Bioinformatics
سال: 2007
ISSN: 1545-5963
DOI: 10.1109/tcbb.2007.1005